3-phenyllactate

Three steps

• oxalateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by AADAT, HAO1cytosol

• glutarateReach from here →
  1. Formation of Phenyl-Lactate
  2. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by AADATcytosol

• L-ornithineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of ornithine and phenylalanine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• glycineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 22 routes

• 2-oxoadipateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by AADATcytosol

• L-dopaReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by GOT2, TAT, SLC7A8cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-histidineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by GOT2, TAT, SLC7A8cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of methionine and phenylalanine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• L-tryptophanReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of phenylalanine and tryptophan (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• L-kynurenineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. Transport of L-Kynurenine

  Catalysed by GOT2, TAT, SLC7A8cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• L-asparagineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of asparagine and phenylalanine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• L-tyrosineReach from here →
  1. Formation of Phenyl-Lactate
  2. Phenylalanine Transaminase, Mitochondrial
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by GOT2, TAT, PAHcytosol, mitochondrial matrix

• 5-amino-2-oxopentanoateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2cytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by AADAT, HOGA1cytosol

• xanthurenateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by AADAT, KYAT3cytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by AADAT, HOGA1cytosol

• 3-methylmalateReach from here →
  1. Formation of Phenyl-Lactate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by AADAT, CLYBLcytosol