O-dodecanoyl-R-carnitine

Three steps

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP1A1 and 4 morecytosol, endoplasmic reticulum

• 11-hydroxydodecanoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. lauric acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 11-hydroxydodecanoate[r]

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol, endoplasmic reticulumOne of 3 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 5 morecytosol, peroxisomeOne of 4 routes

• tetradecanedioyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 7 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, MOGAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, LPCAT2 and 1 morecytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, LPCAT4cytosol

• undecanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 9 morecytosolOne of 3 routes

• N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 4 morecytosol, endoplasmic reticulum

• N-dodecanoyl-(4R)-hydroxysphinganineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N-dodecanoyl-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + dodecanoate

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• 18-hydroxy-(9Z)-octadecenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP4A11 and 1 morecytosol, endoplasmic reticulum

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABHD12cytosol, endoplasmic reticulum

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by CPT1A, CPT1C, CPT1B, PTGS2cytosol, endoplasmic reticulumOne of 2 routes

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by CPT1A, CPT1C, CPT1B, PTGS2cytosol, endoplasmic reticulumOne of 2 routes

• (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by CPT1A, CPT1C, CPT1B, PTGS2cytosol, endoplasmic reticulum

• 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. Arachidonate: oxygen 11-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX12cytosol, endoplasmic reticulumOne of 2 routes

• prostaglandin G2Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. Arachidonate:oxygen oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, PTGS1 and 1 morecytosol, endoplasmic reticulumOne of 2 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP2C9cytosol, endoplasmic reticulum

• 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP1A1 and 26 morecytosol, endoplasmic reticulumOne of 4 routes

• 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP1A1 and 25 morecytosol, endoplasmic reticulumOne of 3 routes

• 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABHD16Acytosol, endoplasmic reticulum

• 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABHD16Acytosol, endoplasmic reticulum

• 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABHD16Acytosol, endoplasmic reticulum

• (5Z)-tetradecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 10 routes

• (3E)-decenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 7 morecytosol, mitochondrial matrix

• 7-hydroxydodecanoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 7-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• N-(dodecanoyl)-sphinganineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N-(dodecanoyl)-sphinganine + H2O = dodecanoate + sphinganine

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 4 morecytosol

• N-tetradecanoylglycineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYATL2cytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 6 morecytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYATL1B and 1 morecytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, ACAA1 and 3 morecytosol

• (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP4F8cytosol, endoplasmic reticulum

• 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX15Bcytosol, endoplasmic reticulum

• 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX15Bcytosol, endoplasmic reticulum