ibuprofen

any adverse event

no effect, OR 0.95, 95% CI 0.64-1.41

There was no statistical difference of any adverse and GI adverse events of ibuprofen compared with placebo and paracetamol (OR: 0.95, 95% CI 0.64–1.41 and OR: 0.81, 95% CI 0.44–1.50, respectively).

PMID:38057585 · one of two readings recorded this

gastrointestinal adverse events

no effect, OR 0.81, 95% CI 0.44-1.50

There was no statistical difference of any adverse and GI adverse events of ibuprofen compared with placebo and paracetamol (OR: 0.95, 95% CI 0.64–1.41 and OR: 0.81, 95% CI 0.44–1.50, respectively).

PMID:38057585 · one of two readings recorded this

occurrence of any adverse event and gastrointestinal adverse events

no effect, OR: 0.95, 95% CI 0.64–1.41 (any AE); OR: 0.81, 95% CI 0.44–1.50 (GI AE)

There was no statistical difference of any adverse and GI adverse events of ibuprofen compared with placebo and paracetamol (OR: 0.95, 95% CI 0.64–1.41 and OR: 0.81, 95% CI 0.44–1.50, respectively).

PMID:38057585 · one of two readings recorded this

pain-free status at 1 hour

no effect, p = 0.66

One study directly compared paracetamol and ibuprofen, and the difference was not statistically significant (P = 0.66).

PMID:38057585 · both readings recorded this

pain-free status at 2 hours after acute treatment for episodic tension-type headache, pooled odds ratio from a network meta-analysis

increases, OR 1.73, 95% CI 1.17-2.56 (ibuprofen), versus paracetamol OR 1.62, 95% CI 1.24-2.13

Not recorded as a finding: this platform holds no node for the endpoint

Ibuprofen (OR: 1.73, 95% CI 1.17–2.56) showed better efficacy than paracetamol (OR: 1.62, 95% CI 1.24–2.13).

PMID:38057585 · one of two readings recorded this

pain-free status at 2 hours (primary outcome)

increases, OR 1.73, 95% CI 1.17-2.56 (ibuprofen) vs OR 1.62, 95% CI 1.24-2.13 (paracetamol)

Ibuprofen (OR: 1.73, 95% CI 1.17–2.56) showed better efficacy than paracetamol (OR: 1.62, 95% CI 1.24–2.13).

PMID:38057585 · one of two readings recorded this

use of rescue medication

unclear, OR 0.49, 95% CI 0.37-0.65 (paracetamol lowest)

Paracetamol was associated with the lowest likelihood of rescue medication use compared with ibuprofen and placebo (OR: 0.49, 95% CI 0.37–0.65).

PMID:38057585 · one of two readings recorded this

dyspepsia incidence

no effect, Risk Difference -0.03, 95% CI [-0.12, 0.06], P = 0.52, p = 0.52

Dyspepsia was investigated in three studies, and the meta-analysis revealed no significant difference between the two groups (Risk Difference: –0.03, 95% CI [–0.12, 0.06], P = 0.52, I2 = 67%, τ = 0.14, 95% PI [–0.63, 0.58]) (Supplementary Material 2).

PMID:38711266 · one of two readings recorded this

need for rescue analgesics

decreases, RR 0.40, 95% CI [0.21, 0.74], P = 0.004, p = 0.004

The requirement for rescue analgesics was significantly lower in the IVB group than in the IVA group (RR: 0.40, 95% CI [0.21, 0.74], P = 0.004, I2 = 39%, τ = 0.41, 95% PI [0.15, 1.09]) (Supplementary Material 2).

PMID:38711266 · one of two readings recorded this

postoperative dyspepsia incidence

no effect, Risk Difference: –0.03, 95% CI [–0.12, 0.06], P = 0.52, p = 0.52

Dyspepsia was investigated in three studies, and the meta-analysis revealed no significant difference between the two groups (Risk Difference: –0.03, 95% CI [–0.12, 0.06], P = 0.52, I2 = 67%, τ = 0.14, 95% PI [–0.63, 0.58]) (Supplementary Material 2).

PMID:38711266 · one of two readings recorded this

postoperative pain score (VAS 0-10) at 24 hours

no effect, MD -0.26, 95% CI [-0.61, 0.10], P = 0.16, p = 0.16

A meta-analysis of five studies showed no significant difference in the pain scores at 24 h postoperatively between the two groups (MD: –0.26, 95% CI [–0.61, 0.10], P = 0.16, I2 = 76%, τ = 0.37, 95% PI [–1.22, 0.70]).

PMID:38711266 · one of two readings recorded this

postoperative pain score (VAS 0-10) at 4-6 hours

decreases, MD -0.83, 95% CI [-1.29, -0.37], P = 0.0004, p = 0.0004

The IVB group showed lower pain intensity than the IVA group (MD: –0.83, 95% CI [–1.29, –0.37], P = 0.0004, I2 = 65%, τ = 0.45, 95% PI [–1.98, 0.32]).

PMID:38711266 · one of two readings recorded this

postoperative pain score (VAS 0-10) at recovery

decreases, MD -1.42, 95% CI [-2.20, -0.65], P = 0.0003, p = 0.0003

A meta-analysis comparing five studies showed that pain scores measured at recovery were lower in the IVB group (MD: –1.42, 95% CI [–2.20, –0.65], P = 0.0003, I2 = 82%, τ = 0.77, 95% PI [–3.57, 0.73]).

PMID:38711266 · one of two readings recorded this

postoperative pain score (VAS) at 24 hours

no effect, MD: –0.26, 95% CI [–0.61, 0.10], P = 0.16, p = 0.16

A meta-analysis of five studies showed no significant difference in the pain scores at 24 h postoperatively between the two groups (MD: –0.26, 95% CI [–0.61, 0.10], P = 0.16, I2 = 76%, τ = 0.37, 95% PI [–1.22, 0.70]).

PMID:38711266 · one of two readings recorded this

postoperative pain score (VAS) at 4–6 hours

decreases, MD: –0.83, 95% CI [–1.29, –0.37], P = 0.0004, p = 0.0004

The IVB group showed lower pain intensity than the IVA group (MD: –0.83, 95% CI [–1.29, –0.37], P = 0.0004, I2 = 65%, τ = 0.45, 95% PI [–1.98, 0.32]).

PMID:38711266 · one of two readings recorded this

postoperative pain score (VAS) at recovery

decreases, MD: –1.42, 95% CI [–2.20, –0.65], P = 0.0003, p = 0.0003

A meta-analysis comparing five studies showed that pain scores measured at recovery were lower in the IVB group (MD: –1.42, 95% CI [–2.20, –0.65], P = 0.0003, I2 = 82%, τ = 0.77, 95% PI [–3.57, 0.73]).

PMID:38711266 · one of two readings recorded this

postoperative pruritus incidence

no effect, Risk Difference: –0.02, 95% CI [–0.07, 0.03], P = 0.42, p = 0.42

Pruritus was reported in seven studies, and the meta-analysis showed no significance (Risk Difference: –0.02, 95% CI [–0.07, 0.03], P = 0.42, I2 = 58%, τ = 0.1, 95% PI [–0.26, 0.22]) (Supplementary Material 2).

PMID:38711266 · one of two readings recorded this

pruritus incidence

no effect, Risk Difference -0.02, 95% CI [-0.07, 0.03], P = 0.42, p = 0.42

Pruritus was reported in seven studies, and the meta-analysis showed no significance (Risk Difference: –0.02, 95% CI [–0.07, 0.03], P = 0.42, I2 = 58%, τ = 0.1, 95% PI [–0.26, 0.22]) (Supplementary Material 2).

PMID:38711266 · one of two readings recorded this

use of rescue analgesics

decreases, RR: 0.40, 95% CI [0.21, 0.74], P = 0.004, p = 0.004

The requirement for rescue analgesics was significantly lower in the IVB group than in the IVA group (RR: 0.40, 95% CI [0.21, 0.74], P = 0.004, I2 = 39%, τ = 0.41, 95% PI [0.15, 1.09]) (Supplementary Material 2).

PMID:38711266 · one of two readings recorded this

asthma exacerbation in children with pre-existing asthma, versus no active alternative

increases

In contrast, it may cause asthma exacerbation for those with pre-existing asthma.

PMID:39187775 · one of two readings recorded this

asthma-like symptoms in the general paediatric population, versus no active alternative, short-term

decreases

Comparing ibuprofen use with no active alternative over a short-term follow-up, ibuprofen may provide protection against asthma-like symptoms in the general population when used to ease symptoms of fever or bronchiolitis.

PMID:39187775 · one of two readings recorded this

asthma or asthma-like symptom development or exacerbation, versus active comparators, short and long term

no effect

Comparing ibuprofen with active comparators, there was no evidence of a higher risk associated with ibuprofen over both the short and long term in either the general or asthmatic population.

PMID:39187775 · one of two readings recorded this

development or exacerbation of asthma or asthma-like symptoms

unclear

Comparing ibuprofen use with no active alternative over a short-term follow-up, ibuprofen may provide protection against asthma-like symptoms in the general population when used to ease symptoms of fever or bronchiolitis.

PMID:39187775 · one of two readings recorded this

adverse events (bronchitis, fever persistence) associated with ibuprofen

unclear

Ibuprofen-associated adverse events were 3 cases of bronchitis and fever persistence.

PMID:39367335 · one of two readings recorded this

adverse events (bronchitis, fever persistence for ibuprofen; hypothermia for dipyrone)

unclear

Ibuprofen-associated adverse events were 3 cases of bronchitis and fever persistence.

PMID:39367335 · one of two readings recorded this

antipyretic effect, mean change in baseline temperature at 30/45/60/120 minutes after drug administration, in febrile children given oral dipyrone versus oral ibuprofen

no effect, -0.03 (95% CI: -0.29, 0.24)

Not recorded as a finding: the comparison was against another active treatment

The pooled estimate of fever reduction revealed similar temperature decrease after 30 min of either dipyrone (203/413) or ibuprofen (210/413) administration by -0.03 (95% CI: -0.29, 0.24) with high heterogeneity between the two drugs (I 2 = 82%).

PMID:39367335 · one of two readings recorded this

temperature decrease at 30 minutes post-administration

no effect, -0.03 (95% CI: -0.29, 0.24), n = 413

The pooled estimate of fever reduction revealed similar temperature decrease after 30 min of either dipyrone (203/413) or ibuprofen (210/413) administration by -0.03 (95% CI: -0.29, 0.24) with high heterogeneity between the two drugs (I 2 = 82%).

PMID:39367335 · one of two readings recorded this

temperature reduction at 30 minutes post-dose

no effect, -0.03 (95% CI: -0.29, 0.24), I2 = 82%

The pooled estimate of fever reduction revealed similar temperature decrease after 30 min of either dipyrone (203/413) or ibuprofen (210/413) administration by -0.03 (95% CI: -0.29, 0.24) with high heterogeneity between the two drugs (I 2 = 82%).

PMID:39367335 · one of two readings recorded this

pain intensity (VAS, 0-10) at 6 hours post-separator placement, ibuprofen vs control

decreases, n = 334

At the 6-hour, 7 studies involving 334 patients revealed significant heterogeneity (I2 = 90%, P <.00001).

PMID:40725907 · one of two readings recorded this

pain intensity (VAS, 0-10), network meta-analysis indirect estimate at 6 and 24 hours, ibuprofen vs control

decreases, MD -1.93 (95% CI -2.93 to -0.93) at 6h; MD -1.63 (95% CI -2.58 to -0.68) at 24h

Similarly, Ibuprofen therapy exhibits a notable efficacy in alleviating pain at 6- and 24-hour post-placement, compared to the control group, with MDs and 95% confidence intervals of −1.93 (−2.93 to −0.93) and −1.63 (−2.58 to −0.68), respectively (Fig. and B).

PMID:40725907 · one of two readings recorded this

pain intensity (VAS) at 6 and 24 hours post-placement, ibuprofen vs control, network meta-analysis pairwise estimate

decreases, MD −1.93, 95% CI (−2.93 to −0.93) at 6 h; MD −1.63, 95% CI (−2.58 to −0.68) at 24 h

Similarly, Ibuprofen therapy exhibits a notable efficacy in alleviating pain at 6- and 24-hour post-placement, compared to the control group, with MDs and 95% confidence intervals of −1.93 (−2.93 to −0.93) and −1.63 (−2.58 to −0.68), respectively (Fig. and B).

PMID:40725907 · one of two readings recorded this

pain intensity (VAS) at 6 hours post-placement, ibuprofen versus control, network meta-analysis pairwise estimate

decreases, MD −1.93, 95% CI (−2.93 to −0.93)

Not recorded as a finding: Same sentence as the recorded 24-hour finding gives a paired 6-hour value; rule E requires recording the overall final-timepoint result once, so the earlier timepoint from the same comparison is not separately claimed.

Similarly, Ibuprofen therapy exhibits a notable efficacy in alleviating pain at 6- and 24-hour post-placement, compared to the control group, with MDs and 95% confidence intervals of −1.93 (−2.93 to −0.93) and −1.63 (−2.58 to ‒0.68), respectively (Fig. and B).

PMID:40725907 · one of two readings recorded this

pain intensity (VAS) at 6 hours post-placement, ibuprofen vs control

decreases, MD = −1.88, 95% CI [−3.07 to −0.70], P =.002, p = 0.002, n = 334

A random-effects model demonstrated a significant reduction in pain (MD = −1.88, 95% CI [−3.07 to −0.70], P =.002) (Table 2, Fig. S2A, Supplemental Digital Content, https://links.lww.com/MD/P534).

PMID:40725907 · one of two readings recorded this

probability of being the optimal (best-ranked) intervention for pain reduction, SUCRA ranking

increases

In the 6-hour of NMA, the Ibuprofen therapy appeared to be the greatest probability (76.9%) to become the optimal intervention.

PMID:40725907 · one of two readings recorded this

surface under the cumulative ranking curve (SUCRA) for pain reduction, ibuprofen versus LLLT and control

increases

It also had the highest mean rank (1.2) in the rankograms and the biggest value of SUCRA (88.4).

PMID:40725907 · one of two readings recorded this

hospital readmission for severe hypertension

no effect, OR 2.03, 95% CI [0.60 to 6.87]; P = 0.25, p = 0.25

The pooled OR was 2.03 (95% CI [0.60 to 6.87]; P = 0.25), indicating no statistically significant difference, with no heterogeneity observed.

PMID:41851234 · one of two readings recorded this

hospital readmission for severe postpartum hypertension

no effect, OR 2.03, 95% CI [0.60 to 6.87]; P = 0.25, p = 0.25

The pooled OR was 2.03 (95% CI [0.60 to 6.87]; P = 0.25), indicating no statistically significant difference, with no heterogeneity observed.

PMID:41851234 · one of two readings recorded this

length of postpartum hospital stay

no effect, MD -0.03 days, 95% CI [-0.24 to 0.18]; P = 0.77, p = 0.77

Pooled analysis showed no statistically significant difference (MD −0.03 days, 95% CI [−0.24 to 0.18]; P = 0.77), with no heterogeneity between studies Table 3.

PMID:41851234 · both readings recorded this

postpartum antihypertensive medication use

no effect, OR 1.00, 95% CI [0.61 to 1.63]; P = 1.00, p = 1

There was no between-group difference (OR 1.00, 95 % CI [0.61 to 1.63]; P = 1.00; I2 = 0 %).

PMID:41851234 · both readings recorded this

postpartum diastolic blood pressure

no effect, MD 1.81 mmHg, 95% CI [−0.26 to 3.88]; P = 0.09, p = 0.09

Pooled analysis again showed no statistically significant difference (MD 1.81 mmHg, 95% CI [−0.26 to 3.88]; P = 0.09), with low heterogeneity across the studies (I2 = 39%) (Figure and Figure 4).

PMID:41851234 · both readings recorded this

postpartum diuresis achievement

no effect, OR 0.78, 95% CI [0.44 to 1.40]; P = 0.40, p = 0.4

Pooled analysis again showed no significant difference (OR 0.78, 95% CI [0.44 to 1.40]; P = 0.40), with no heterogeneity.

PMID:41851234 · both readings recorded this

postpartum mean arterial pressure (MAP), among other blood-pressure and recovery outcomes, pooled across RCTs comparing ibuprofen with acetaminophen

no effect, MD 0.03 mmHg, 95% CI [−1.82 to 1.88], P = 0.97, p = 0.97

Not recorded as a finding: the comparison was against another active treatment

Pooled analysis showed no statistically significant difference between the two groups (MD 0.03 mmHg, 95% CI [−1.82 to 1.88], P = 0.97), with no heterogeneity observed (I2 = 0%).

PMID:41851234 · one of two readings recorded this

postpartum mean arterial pressure

no effect, MD 0.03 mmHg, 95% CI [−1.82 to 1.88], P = 0.97, p = 0.97

Pooled analysis showed no statistically significant difference between the two groups (MD 0.03 mmHg, 95% CI [−1.82 to 1.88], P = 0.97), with no heterogeneity observed (I2 = 0%).

PMID:41851234 · both readings recorded this

postpartum opioid use for inadequate pain control

no effect, OR 1.12, 95% CI [0.63 to 2.00]; P = 0.69, p = 0.69

Pooled analysis revealed no significant difference (OR 1.12, 95% CI [0.63 to 2.00]; P = 0.69), and no heterogeneity was noted.

PMID:41851234 · both readings recorded this

postpartum systolic blood pressure

no effect, MD 1.31 mmHg, 95% CI [−1.60 to 4.22]; P = 0.38, p = 0.38

Pooled analysis demonstrated no statistically significant difference between the groups (MD 1.31 mmHg, 95% CI [−1.60 to 4.22]; P = 0.38), with no heterogeneity observed (I2 = 0%).

PMID:41851234 · both readings recorded this

severe postpartum hypertension incidence requiring antihypertensive therapy (generally SBP >=160 mmHg or DBP >=110 mmHg), pooled odds ratio

no effect, OR 1.15, 95% CI [0.75 to 1.75]; P = 0.52; I2 = 0%, p = 0.52

Not recorded as a finding: the comparison was against another active treatment

Pooled analysis showed no difference between ibuprofen and acetaminophen (OR 1.15, 95 % CI [0.75 to 1.75]; P = 0.52; I2 = 0 %).

PMID:41851234 · one of two readings recorded this

severe postpartum hypertension incidence requiring antihypertensive therapy

no effect, OR 1.15, 95% CI [0.75 to 1.75]; P = 0.52; I2 = 0%, p = 0.52

Pooled analysis showed no difference between ibuprofen and acetaminophen (OR 1.15, 95 % CI [0.75 to 1.75]; P = 0.52; I2 = 0 %).

PMID:41851234 · one of two readings recorded this

severe postpartum hypertension incidence

no effect, OR 1.15, 95% CI [0.75 to 1.75]; P = 0.52; I2 = 0%, p = 0.52

Pooled analysis showed no difference between ibuprofen and acetaminophen (OR 1.15, 95 % CI [0.75 to 1.75]; P = 0.52; I2 = 0 %).

PMID:41851234 · one of two readings recorded this

time to postpartum blood pressure control

no effect, MD -4.21 hours, 95% CI [-8.86 to 0.44]; P = 0.08, p = 0.08

The MD was −4.21 hours (95 % CI [−8.86 to 0.44], P = 0.08; I2 = 16 %).

PMID:41851234 · both readings recorded this