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Proteins/UNIPROT:P30531
Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity)..
Function from UniProtKB (P30531), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
73 statements
73 statements · 7 reference databases · Subject: SLC6A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
4-aminobutanoate+2sodium(1+)4-aminobutanoate+2sodium(1+)
Transported by SLC6A13 or SLC6A12 or SLC6A11 or SLC6A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04691CC BY 4.0Reference data
5 names
Resolves to: SLC6A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09613CC BY 4.0Reference data
4-aminobutanoate+chloride+2sodium(1+)4-aminobutanoate+chloride+2sodium(1+)
Transported by SLC6A1 or SLC6A6 or SLC6A11 or SLC6A13
Reaction pageReversibleBalanced
Rhea RHEA:70687CC BY 4.0Reference data
hypotaurine+chloride+2sodium(1+)hypotaurine+chloride+2sodium(1+)
Transported by SLC6A1 or SLC6A6 or SLC6A11 or SLC6A13
Reaction pageLeft to rightBalanced
Rhea RHEA:71243CC BY 4.0Reference data