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Proteins/UNIPROT:Q14642
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity)..
Function from UniProtKB (Q14642), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 7 reference databases · Subject: INPP5A · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
1D-myo-inositol 1,4,5-trisphosphate+waterMAM00526c+phosphate(3-)
Catalysed by INPP5A or INPP5K or INPP5J
Reaction pageLeft to rightBalancedEC 3.1.3.56cytosol
Human-GEM MAR06560CC BY 4.0Reference data
MAM00522c+waterMAM00524c+phosphate(3-)
3 names
Resolves to: INPP5A
Reaction pageLeft to rightBalancedEC 3.1.3.56, 3.1.3.86cytosol
Human-GEM MAR06565CC BY 4.0Reference data
CHEBI:57895+waterCHEBI:58414+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or OCRL or INPP5A or INPP5J or INPP5D or INPP5K
Reaction pageLeft to rightBalanced
Rhea RHEA:11392CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data