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Proteins/UNIPROT:Q15181
Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules. Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation (By similarity)..
Function from UniProtKB (Q15181), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
30 statements
30 statements · 3 reference databases · Subject: PPA1 · Sources: Hetionet, Reactome, UniProt
6 reactions
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1endoplasmic reticulum
Human-GEM MAR03975CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by
4 names
Resolves to: PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1cytosol
Human-GEM MAR03977CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1peroxisome
Human-GEM MAR03979CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1mitochondrial matrix
Human-GEM MAR06912CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1nucleus
Human-GEM MAR07794CC BY 4.0Reference data
diphosphate(3-)+water2hydrogenphosphate+hydron
Catalysed by ALPL or PPA1 or LHPP or PPA2
Reaction pageLeft to rightBalanced
Rhea RHEA:24576CC BY 4.0Reference data