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Proteins/UNIPROT:P27815
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes..
[Isoform 1]: Efficiently hydrolyzes cAMP..
[Isoform 2]: Efficiently hydrolyzes cAMP..
[Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP..
[Isoform 4]: Efficiently hydrolyzes cAMP..
[Isoform 6]: Efficiently hydrolyzes cAMP..
[Isoform 7]: Efficiently hydrolyzes cAMP..
Function from UniProtKB (P27815), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 7 reference databases · Subject: PDE4A · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
3 names
Resolves to: PDE4A
Human-GEM MAR04014CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+proton
Catalysed by PDE4A or PDE8A or PDE4C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6H or PDE3B or PDE1C and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08087CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+hydron
Catalysed by PDE2A or PDE8A or PDE8B or ENPP1 or PDE4A or PDE1A or PDE1B or PDE4B or PDE4C or PDE4D or PDE3B or PDE7A and 6 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:25277CC BY 4.0Reference data