Proteins/UNIPROT:Q9Y490

TLN1

ProteinUNIPROT:Q9Y490

High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims..

Function from UniProtKB (Q9Y490), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

idiopathic spontaneous coronary artery dissection has a germline basis in TLN1DiseaseGenCC HGNC:11845|MONDO:0007385Inferred only

Statements

69 statements

69 statements · 4 reference databases · Subject: TLN1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TLN1 covaries with WNT7BProteinHetionet hetionet:covaries:7094-7477Inferred only
TLN1 covaries with ZIC1ProteinHetionet hetionet:covaries:7094-7545Inferred only
TLN1 interacts with ABI1ProteinHetionet hetionet:interacts:10006-7094Inferred only
CDK2 interacts with TLN1ProteinHetionet hetionet:interacts:1017-7094Inferred only
CDK5 interacts with TLN1ProteinHetionet hetionet:interacts:1020-7094Inferred only
DAG1 interacts with TLN1ProteinHetionet hetionet:interacts:1605-7094Inferred only
EGFR interacts with TLN1ProteinHetionet hetionet:interacts:1956-7094Inferred only
ERBB2 interacts with TLN1ProteinHetionet hetionet:interacts:2064-7094Inferred only
TLN1 interacts with FAM114A1ProteinHetionet hetionet:interacts:7094-92689Inferred only
ITGA1 interacts with TLN1ProteinHetionet hetionet:interacts:3672-7094Inferred only
ITGA4 interacts with TLN1ProteinHetionet hetionet:interacts:3676-7094Inferred only
ITGB1 interacts with TLN1ProteinHetionet hetionet:interacts:3688-7094Inferred only

Show the remaining 57

ITGB3 interacts with TLN1ProteinHetionet hetionet:interacts:3690-7094Inferred only
TLN1 interacts with PRDX4ProteinHetionet hetionet:interacts:10549-7094Inferred only
PTK2B interacts with TLN1ProteinHetionet hetionet:interacts:2185-7094Inferred only
PXN interacts with TLN1ProteinHetionet hetionet:interacts:5829-7094Inferred only
TLN1 interacts with SIRT7ProteinHetionet hetionet:interacts:51547-7094Inferred only
TLN1 interacts with SMURF1ProteinHetionet hetionet:interacts:57154-7094Inferred only
SUMO2 interacts with TLN1ProteinHetionet hetionet:interacts:6613-7094Inferred only
TERF2 interacts with TLN1ProteinHetionet hetionet:interacts:7014-7094Inferred only
TLN1 interacts with TESProteinHetionet hetionet:interacts:26136-7094Inferred only
TLN1 interacts with TUBA1AProteinHetionet hetionet:interacts:7094-7846Inferred only
TLN1 interacts with UBCProteinHetionet hetionet:interacts:7094-7316Inferred only
TLN1 interacts with VCAM1ProteinHetionet hetionet:interacts:7094-7412Inferred only
TLN1 interacts with YWHAZProteinHetionet hetionet:interacts:7094-7534Inferred only
TLN1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
TLN1 participates in Cellular responses to mechanical stimuliPathwayReactome R-HSA-9855142Inferred only
TLN1 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
TLN1 participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
TLN1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
TLN1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
TLN1 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
TLN1 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
TLN1 participates in GRB2:SOS provides linkage to MAPK signaling for IntegrinsPathwayReactome R-HSA-354194Inferred only
TLN1 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
TLN1 participates in High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cellsPathwayReactome R-HSA-9856530Inferred only
TLN1 participates in Integrin mediated cell adhesionPathwayWikiPathways WP185Inferred only
TLN1 participates in Integrin signalingPathwayReactome R-HSA-354192Inferred only
TLN1 participates in IRE1alpha activates chaperonesPathwayReactome R-HSA-381070Inferred only
TLN1 participates in MAP2K and MAPK activationPathwayReactome R-HSA-5674135Inferred only
TLN1 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
TLN1 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
TLN1 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
TLN1 participates in Nanoparticle mediated activation of receptor signalingPathwayWikiPathways WP2643Inferred only
TLN1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
TLN1 participates in Oncogenic MAPK signalingPathwayReactome R-HSA-6802957Inferred only
TLN1 participates in p130Cas linkage to MAPK signaling for integrinsPathwayReactome R-HSA-372708Inferred only
TLN1 participates in Paradoxical activation of RAF signaling by kinase inactive BRAFPathwayReactome R-HSA-6802955Inferred only
TLN1 participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
TLN1 participates in Platelet Aggregation (Plug Formation)PathwayReactome R-HSA-76009Inferred only
TLN1 participates in Platelet degranulationPathwayReactome R-HSA-114608Inferred only
TLN1 participates in Primary focal segmental glomerulosclerosis FSGS PathwayWikiPathways WP2572Inferred only
TLN1 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
TLN1 participates in Response of endothelial cells to shear stressPathwayReactome R-HSA-9860931Inferred only
TLN1 participates in Response to elevated platelet cytosolic Ca2+PathwayReactome R-HSA-76005Inferred only
TLN1 participates in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionPathwayReactome R-HSA-399955Inferred only
TLN1 participates in Semaphorin interactionsPathwayReactome R-HSA-373755Inferred only
TLN1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TLN1 participates in Signaling by BRAF and RAF1 fusionsPathwayReactome R-HSA-6802952Inferred only
TLN1 participates in Signaling by high-kinase activity BRAF mutantsPathwayReactome R-HSA-6802948Inferred only
TLN1 participates in Signaling by moderate kinase activity BRAF mutantsPathwayReactome R-HSA-6802946Inferred only
TLN1 participates in Signaling by RAF1 mutantsPathwayReactome R-HSA-9656223Inferred only
TLN1 participates in Signaling by RAS mutantsPathwayReactome R-HSA-6802949Inferred only
TLN1 participates in Signaling downstream of RAS mutantsPathwayReactome R-HSA-9649948Inferred only
TLN1 participates in Smooth Muscle ContractionPathwayReactome R-HSA-445355Inferred only
TLN1 participates in TROP2 regulatory signalingPathwayWikiPathways WP5300Inferred only
TLN1 participates in Unfolded Protein Response (UPR)PathwayReactome R-HSA-381119Inferred only
TLN1 participates in XBP1(S) activates chaperone genesPathwayReactome R-HSA-381038Inferred only
TLN1 regulates regulation of focal adhesion assemblyBiological processgene ontology Q9Y490|GO:0051893Inferred only

Other names

3 names

Resolves to: TLN1

Also called: KIAA1027Talin-1TLN

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