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Proteins/UNIPROT:P00747
[Plasmin]: Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor (VWF). Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation. In ovulation, weakens the walls of the Graafian follicle (By similarity). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5..
[Angiostatin]: Has an antiangiogenic activity and inhibits neovascularization. Could act through the inhibition of the ATP synthase subunit ATP5F1A..
(Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue..
(Microbial infection) Interacts with dengue virus type 2 particles. Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes..
Function from UniProtKB (P00747), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
95 statements
95 statements · 5 reference databases · Subject: PLG · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
1 reaction
2430ATP+62Gly-tRNA(Gly)+2431water+37Ala-tRNA(Ala)+42MAM02340c+40Asn-tRNA(Asn)+36Asp-tRNA(Asp)+48Cys-tRNA(Cys)+31Gln-tRNA(Gln)+56MAM02377c+24MAM02380c+22Ile-tRNA(Ile)+48MAM02404c+49MAM02405c+11
1 name
Resolves to: PLG
Catalysed by PLG
Reaction pageLeft to rightBalance undeterminableEC 3.4.21.7cytosol
Human-GEM MAR05162CC BY 4.0Reference data