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Proteins/UNIPROT:Q03591

CFHR1

Protein·UNIPROT:Q03591

Open in the graph

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism..

Function from UniProtKB (Q03591), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

dense deposit disease has a germline basis in CFHR1DiseaseGenCC HGNC:4888|MONDO:0019736Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: CFHR1 · Sources: gene ontology, Hetionet, Reactome

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APOA1 interacts with CFHR1ProteinHetionet hetionet:interacts:3078-335Inferred only
CFH interacts with CFHR1ProteinHetionet hetionet:interacts:3075-3078Inferred only
CFHR1 interacts with LBPProteinHetionet hetionet:interacts:3078-3929Inferred only
CFHR1 interacts with PRDX4ProteinHetionet hetionet:interacts:10549-3078Inferred only
CFHR1 participates in Complement cascadePathwayReactome R-HSA-166658Inferred only
CFHR1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CFHR1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CFHR1 participates in Regulation of Complement cascadePathwayReactome R-HSA-977606Inferred only
CFHR1 regulates positive regulation of complement activationBiological processgene ontology Q03591|GO:0045917Inferred only

Other names

12 names

Resolves to: CFHR1

Also called: CFHLCFHL1CFHL1PCFHR1PFHL-1FHR-1FHR1H factor-like protein 1H-factor-like 1H36HFL1HFL2

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