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Proteins/UNIPROT:P30101
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity..
Function from UniProtKB (P30101), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
64 statements
64 statements · 4 reference databases · Subject: PDIA3 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
1 reaction
2CHEBI:16856+MAM03169cglutathione disulfide+MAM03170c
Catalysed by PDIA5 or PDIA6 or PDIA4 or TMX3 or PDIA3 or P4HB
Reaction pageLeft to rightBalancedEC 5.3.4.1cytosol
Human-GEM MAR09806CC BY 4.0Reference data
11 names
Resolves to: PDIA3