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Proteins/UNIPROT:Q96PM5
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation..
[Isoform 4]: Has no E3 ubiquitin-protein ligase activity..
Function from UniProtKB (Q96PM5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
91 statements
91 statements · 4 reference databases · Subject: RCHY1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
13 names
Resolves to: RCHY1
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data