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Proteins/UNIPROT:Q92598
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)..
Function from UniProtKB (Q92598), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 3 reference databases · Subject: HSPH1 · Sources: gene ontology, Hetionet, Reactome
6 names
Resolves to: HSPH1