negative regulation of pyruvate decarboxylation to acetyl-CoA

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions.

Definition from the Gene Ontology (GO:0160218), read 2026-09-23. CC BY 4.0.