Pathway

TFAP2 (AP-2) family regulates transcription of cell cycle factors

TFAP2A and TFAP2C play opposing roles in transcriptional regulation of the CDKN1A (p21) gene locus. While TFAP2A stimulates transcription of the CDKN1A cyclin-dependent kinase inhibitor, TFAP2C, in cooperation with MYC and histone demethylase KDM5B, represses CDKN1A transcription.

Summary from Reactome (R-HSA-8866911), read 2026-09-23.

REACT:R-HSA-8866911Reactome

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What the reference databases state

Statements

5 statements

5 statements · 1 reference database · Subject: TFAP2 (AP-2) family regulates transcription of cell cycle factors · Sources: Reactome

Order

CDKN1A participates in TFAP2 (AP-2) family regulates transcription of cell cycle factorsProteinReactome R-HSA-8866911Inferred only
KDM5B participates in TFAP2 (AP-2) family regulates transcription of cell cycle factorsProteinReactome R-HSA-8866911Inferred only
MYC participates in TFAP2 (AP-2) family regulates transcription of cell cycle factorsProteinReactome R-HSA-8866911Inferred only
TFAP2A participates in TFAP2 (AP-2) family regulates transcription of cell cycle factorsProteinReactome R-HSA-8866911Inferred only
TFAP2C participates in TFAP2 (AP-2) family regulates transcription of cell cycle factorsProteinReactome R-HSA-8866911Inferred only