Proteins/UNIPROT:O43147

SGSM2

ProteinUNIPROT:O43147

Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation..

Function from UniProtKB (O43147), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 1 reference database · Subject: SGSM2 · Sources: Hetionet

Order

AFP interacts with SGSM2ProteinHetionet hetionet:interacts:174-9905Inferred only
CA12 interacts with SGSM2ProteinHetionet hetionet:interacts:771-9905Inferred only
CELSR3 interacts with SGSM2ProteinHetionet hetionet:interacts:1951-9905Inferred only
CHD3 interacts with SGSM2ProteinHetionet hetionet:interacts:1107-9905Inferred only
EGFR interacts with SGSM2ProteinHetionet hetionet:interacts:1956-9905Inferred only
SGSM2 interacts with FNBP1LProteinHetionet hetionet:interacts:54874-9905Inferred only
SGSM2 interacts with GDPD2ProteinHetionet hetionet:interacts:54857-9905Inferred only
ILF2 interacts with SGSM2ProteinHetionet hetionet:interacts:3608-9905Inferred only
SGSM2 interacts with KHDRBS3ProteinHetionet hetionet:interacts:10656-9905Inferred only
MPP1 interacts with SGSM2ProteinHetionet hetionet:interacts:4354-9905Inferred only
SGSM2 interacts with PNO1ProteinHetionet hetionet:interacts:56902-9905Inferred only
PTN interacts with SGSM2ProteinHetionet hetionet:interacts:5764-9905Inferred only

Show the remaining 8

SGSM2 interacts with RGMAProteinHetionet hetionet:interacts:56963-9905Inferred only
RPS25 interacts with SGSM2ProteinHetionet hetionet:interacts:6230-9905Inferred only
RXRB interacts with SGSM2ProteinHetionet hetionet:interacts:6257-9905Inferred only
ARF4 increases the expression of SGSM2ProteinHetionet hetionet:regulates:378-9905Inferred only
BRAF increases the expression of SGSM2ProteinHetionet hetionet:regulates:673-9905Inferred only
DYNLL1 increases the expression of SGSM2ProteinHetionet hetionet:regulates:8655-9905Inferred only
JAZF1 increases the expression of SGSM2ProteinHetionet hetionet:regulates:221895-9905Inferred only
LIG1 increases the expression of SGSM2ProteinHetionet hetionet:regulates:3978-9905Inferred only

Other names

4 names

Resolves to: SGSM2

Also called: KIAA0397RUN and TBC1 domain-containing protein 1RUTBC1Small G protein signaling modulator 2

← Every protein Find it in the graph →