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Proteins/UNIPROT:Q14802
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes..
[Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials..
[Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials..
Function from UniProtKB (Q14802), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
36 statements
36 statements · 3 reference databases · Subject: FXYD3 · Sources: gene ontology, Hetionet, Reactome
6 names
Resolves to: FXYD3