Proteins/UNIPROT:Q86WJ1

CHD1L

ProteinUNIPROT:Q86WJ1

ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin..

Function from UniProtKB (Q86WJ1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

32 statements

32 statements · 3 reference databases · Subject: CHD1L · Sources: Hetionet, Reactome, WikiPathways

Order

HINT2 covaries with CHD1LProteinHetionet hetionet:covaries:84681-9557Inferred only
TAS2R14 covaries with CHD1LProteinHetionet hetionet:covaries:50840-9557Inferred only
H2AC18; H2AC19 interacts with CHD1LProteinHetionet hetionet:interacts:8337-9557Inferred only
CHD1L interacts with H2AC18; H2AC19ProteinHetionet hetionet:interacts:723790-9557Inferred only
CHD1L interacts with H2AC25ProteinHetionet hetionet:interacts:92815-9557Inferred only
H2AX interacts with CHD1LProteinHetionet hetionet:interacts:3014-9557Inferred only
H2AZ1 interacts with CHD1LProteinHetionet hetionet:interacts:3015-9557Inferred only
CHD1L interacts with H2BC12ProteinHetionet hetionet:interacts:85236-9557Inferred only
H2BC3 interacts with CHD1LProteinHetionet hetionet:interacts:3018-9557Inferred only
H3-3A; H3-3B interacts with CHD1LProteinHetionet hetionet:interacts:3021-9557Inferred only
H3-3A; H3-3B interacts with CHD1LProteinHetionet hetionet:interacts:3020-9557Inferred only
NR4A1 interacts with CHD1LProteinHetionet hetionet:interacts:3164-9557Inferred only

Show the remaining 20

PARP1 interacts with CHD1LProteinHetionet hetionet:interacts:142-9557Inferred only
CHD1L interacts with PARP2ProteinHetionet hetionet:interacts:10038-9557Inferred only
PRKDC interacts with CHD1LProteinHetionet hetionet:interacts:5591-9557Inferred only
RPA3 interacts with CHD1LProteinHetionet hetionet:interacts:6119-9557Inferred only
CHD1L interacts with SCYL1ProteinHetionet hetionet:interacts:57410-9557Inferred only
SUMO2 interacts with CHD1LProteinHetionet hetionet:interacts:6613-9557Inferred only
UBC interacts with CHD1LProteinHetionet hetionet:interacts:7316-9557Inferred only
CHD1L interacts with UBE2OProteinHetionet hetionet:interacts:63893-9557Inferred only
XRCC5 interacts with CHD1LProteinHetionet hetionet:interacts:7520-9557Inferred only
XRCC6 interacts with CHD1LProteinHetionet hetionet:interacts:2547-9557Inferred only
CHD1L participates in 1q21 1 copy number variation syndromePathwayWikiPathways WP4905Inferred only
CHD1L participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
CHD1L participates in Dual Incision in GG-NERPathwayReactome R-HSA-5696400Inferred only
CHD1L participates in Formation of Incision Complex in GG-NERPathwayReactome R-HSA-5696395Inferred only
CHD1L participates in Global Genome Nucleotide Excision Repair (GG-NER)PathwayReactome R-HSA-5696399Inferred only
CHD1L participates in Nucleotide Excision RepairPathwayReactome R-HSA-5696398Inferred only
CHD1L participates in Nucleotide excision repair in xeroderma pigmentosum PathwayWikiPathways WP5114Inferred only
ABCA3 decreases the expression of CHD1LProteinHetionet hetionet:regulates:21-9557Inferred only
ERG decreases the expression of CHD1LProteinHetionet hetionet:regulates:2078-9557Inferred only
RPS7 increases the expression of CHD1LProteinHetionet hetionet:regulates:6201-9557Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

3 names

Resolves to: CHD1L

Also called: ALC1Amplified in liver cancer protein 1Chromo domain-containing protein 1-like

← Every protein Find it in the graph →