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Proteins/UNIPROT:Q8WUW1

BRK1

Protein·UNIPROT:Q8WUW1

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Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)..

Function from UniProtKB (Q8WUW1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

37 statements

37 statements · 4 reference databases · Subject: BRK1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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BRK1 covaries with ARL2ProteinHetionet hetionet:covaries:402-55845Inferred only
BRK1 covaries with HNRNPFProteinHetionet hetionet:covaries:3185-55845Inferred only
BRK1 covaries with PRPSAP2ProteinHetionet hetionet:covaries:55845-5636Inferred only
CYFIP2 interacts with BRK1ProteinHetionet hetionet:interacts:26999-55845Inferred only
NCK1 interacts with BRK1ProteinHetionet hetionet:interacts:4690-55845Inferred only
NCKAP1 interacts with BRK1ProteinHetionet hetionet:interacts:10787-55845Inferred only
PFDN1 interacts with BRK1ProteinHetionet hetionet:interacts:5201-55845Inferred only
UBC interacts with BRK1ProteinHetionet hetionet:interacts:55845-7316Inferred only
WASF1 interacts with BRK1ProteinHetionet hetionet:interacts:55845-8936Inferred only
BRK1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
BRK1 participates in Fcgamma receptor (FCGR) dependent phagocytosisPathwayReactome R-HSA-2029480Inferred only
BRK1 participates in FCGR3A-mediated phagocytosisPathwayReactome R-HSA-9664422Inferred only

Show the remaining 25

BRK1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
BRK1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
BRK1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
BRK1 participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
BRK1 participates in Leishmania phagocytosisPathwayReactome R-HSA-9664417Inferred only
BRK1 participates in Parasite infectionPathwayReactome R-HSA-9664407Inferred only
BRK1 participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
BRK1 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
BRK1 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
BRK1 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
BRK1 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
BRK1 participates in Regulation of actin dynamics for phagocytic cup formationPathwayReactome R-HSA-2029482Inferred only
BRK1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
BRK1 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
BRK1 participates in RHO GTPases Activate WASPs and WAVEsPathwayReactome R-HSA-5663213Inferred only
BRK1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
BRK1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
BRK1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
BRK1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
BRK1 participates in Signaling by VEGFPathwayReactome R-HSA-194138Inferred only
BRK1 participates in VEGFA-VEGFR2 PathwayPathwayReactome R-HSA-4420097Inferred only
BRK1 regulates positive regulation of Arp2/3 complex-mediated actin nucleationBiological processgene ontology Q8WUW1|GO:2000601Inferred only
BRK1 regulates positive regulation of lamellipodium assemblyBiological processgene ontology Q8WUW1|GO:0010592Inferred only
BRK1 regulates positive regulation of protein-containing complex assemblyBiological processgene ontology Q8WUW1|GO:0031334Inferred only
BRK1 regulates regulation of actin polymerization or depolymerizationBiological processgene ontology Q8WUW1|GO:0008064Inferred only

Other names

3 names

Resolves to: BRK1

Also called: BRICK1C3orf10Protein BRICK1

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