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Proteins/UNIPROT:Q6ZW31

SYDE1

Protein·UNIPROT:Q6ZW31

Open in the graph

GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1..

Function from UniProtKB (Q6ZW31), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

16 statements

16 statements · 3 reference databases · Subject: SYDE1 · Sources: gene ontology, Hetionet, Reactome

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UBC interacts with SYDE1ProteinHetionet hetionet:interacts:7316-85360Inferred only
SYDE1 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
SYDE1 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
SYDE1 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
SYDE1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
SYDE1 participates in RHOF GTPase cyclePathwayReactome R-HSA-9035034Inferred only
SYDE1 participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only
SYDE1 participates in RHOQ GTPase cyclePathwayReactome R-HSA-9013406Inferred only
SYDE1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SYDE1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
SYDE1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
SYDE1 regulates positive regulation of trophoblast cell migrationBiological processgene ontology Q6ZW31|GO:1901165Inferred only

Show the remaining 4

SYDE1 regulates regulation of cytoskeleton organizationBiological processgene ontology Q6ZW31|GO:0051493Inferred only
SYDE1 regulates regulation of Ras protein signal transductionBiological processgene ontology Q6ZW31|GO:0046578Inferred only
BECN1 increases the expression of SYDE1ProteinHetionet hetionet:regulates:8678-85360Inferred only
SRSF2 increases the expression of SYDE1ProteinHetionet hetionet:regulates:6427-85360Inferred only

Other names

3 names

Resolves to: SYDE1

Also called: Protein syd-1 homolog 1syd-1 homolog 1Synapse defective protein 1 homolog 1

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