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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q96BY6

DOCK10

Protein·UNIPROT:Q96BY6

Open in the graph

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression..

Function from UniProtKB (Q96BY6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

18 statements

18 statements · 3 reference databases · Subject: DOCK10 · Sources: gene ontology, Hetionet, Reactome

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DOCK10 interacts with LURAP1ProteinHetionet hetionet:interacts:541468-55619Inferred only
DOCK10 interacts with RHOJProteinHetionet hetionet:interacts:55619-57381Inferred only
UBC interacts with DOCK10ProteinHetionet hetionet:interacts:55619-7316Inferred only
DOCK10 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
DOCK10 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
DOCK10 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
DOCK10 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
DOCK10 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
DOCK10 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
DOCK10 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DOCK10 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DOCK10 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only

Show the remaining 6

DOCK10 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
DOCK10 regulates positive regulation of GTPase activityBiological processgene ontology Q96BY6|GO:0043547Inferred only
DOCK10 regulates regulation of cell migrationBiological processgene ontology Q96BY6|GO:0030334Inferred only
DOCK10 regulates regulation of postsynapse assemblyBiological processgene ontology Q96BY6|GO:0150052Inferred only
DOCK10 regulates regulation of Rho protein signal transductionBiological processgene ontology Q96BY6|GO:0035023Inferred only
GSK3B increases the expression of DOCK10ProteinHetionet hetionet:regulates:2932-55619Inferred only

Other names

4 names

Resolves to: DOCK10

Also called: Dedicator of cytokinesis protein 10KIAA0694ZIZ3Zizimin-3

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