prostaglandin H1

Three steps

• taurolithocholate 3-sulfateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• histamineReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• L-thyroxineReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by PTGES, PTGES3, PTGES2, SLCO2A1 and 1 morecytosol, extracellular space, mitochondrial matrix

• dopamineReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by PTGES, PTGES3, PTGES2, SLCO2A1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 6 routes

• L-cysteinylglycineReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by PTGES, PTGES3, PTGES2, SLCO2A1 and 6 morecytosol, extracellular spaceOne of 4 routes

• (R)-noradrenalineReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• thromboxane B2Reach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1cytosol, extracellular spaceOne of 6 routes

• taurochenodeoxycholateReach from here →
  1. prostaglandin-E synthase (prostaglandin E1)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by PTGES, PTGES3, PTGES2, SLCO1B1 and 3 morecytosol, extracellular spaceOne of 4 routes