a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

313 compounds within 3 steps: 11 in 1, 35 in 2, 267 in 3

Three steps

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 5 routes
N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane
a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phosphate(out) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phosphate(in) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)
2. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
3. a 1-acyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by PITPNM1, TAFAZZIN, LCLAT1inner side of the membrane, outer side of the membrane
nonadecanoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 3 routes
a 2,3-diacyl-sn-glycerolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)
2. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + a 2-acylglycerol + H(+)
3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA
Catalysed by DDHD1, GDPD2, MOGAT2, MOGAT1One of 2 routes
1-O-alkyl-3-acylglycerolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
dodecanedioyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Activation of dodecanedioic acid
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 9 morecytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Production of Sebacoylcarnitine
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Production of Suberylcarnitine
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 9 morecytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 5 routes
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. a 1,2-diacyl-sn-glycero-3-phosphate(out) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phosphate(in) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)
2. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
Catalysed by PITPNM1, TAFAZZIN, PLA2G15, DDHD1inner side of the membrane, outer side of the membraneOne of 2 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosol
(13Z)-eicosenoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 17 morecytosolOne of 5 routes
1-O-alkyl-2,3-diacyl-sn-glycerolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
(25R)-cholest-5-ene-3beta,26-diolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (25R)-cholest-5-ene-3beta,26-diol + 2 oxidized [adrenodoxin] + H2O
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane
4,8-dimethylnonanoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 11 morecytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 13 morecytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. Production of Hexadecanedioylcarnitine
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 12 morecytosolOne of 2 routes
1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(out) + cholesterol(in) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(in) + cholesterol(out)
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
(11Z,14Z)-eicosadienoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. 1,2-diacyl-sn-glycerol acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. 1,2-diacyl-sn-glycerol acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. 1,2-diacyl-sn-glycerol acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. 1,2-diacyl-sn-glycerol acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes
pristanoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. fatty-acid-CoA ligase
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 10 morecytosolOne of 2 routes
undecanoyl-CoAReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 15 morecytosolOne of 3 routes
N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. 1,2-diacyl-sn-glycerol acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes
N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes
N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes
an N-acyl-(4R)-4-hydroxysphinganine-phosphocholineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes
N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 8 moreOne of 2 routes
an N-acylsphinganine-1-phosphoethanolamineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 8 moreOne of 2 routes
N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 8 moreOne of 2 routes
an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 8 moreOne of 2 routes
hexadecanoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
3. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 7 more
tricosanoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. 1,2-diacyl-sn-glycerol acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 5 moreextracellular spaceOne of 12 routes
cholesteryl octadecanoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane
cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 6 more
1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)
2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by PLCG1, PLCD1, PLCB2, PLCB3 and 6 more
cholesteryl (9Z)-hexadecenoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
3. 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (8Z,11Z,14Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane
a monoacyl-sn-glycero-3-phosphocholineReach from here →
1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 moreinner side of the membrane, outer side of the membrane