(2E,6E)-farnesyl diphosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

83 compounds within 3 steps: 10 in 1, 6 in 2, 67 in 3

Three steps

3,3',5'-triiodothyronamineReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2
Catalysed by COX10, COX15, DIO3mitochondrial matrix
iron(2+)Reach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
3. Heme Oxygenase 1
Catalysed by COX10, HMOX1, HMOX2mitochondrial matrix, cytosolOne of 2 routes
hydrogenselenideReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by COX10, COX15, SCLYmitochondrial matrix
25-hydroxycholesterolReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by COX10, COX15, CH25Hmitochondrial matrix
all-trans-13,14-dihydroretinolReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by COX10, COX15, RETSATmitochondrial matrix
3,3',5-triiodo-L-thyronineReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrix
deoxyhemoglobinReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
3. globin to hemoglobin conversion
Catalysed by COX10mitochondrial matrix, cytosol
3,3',5'-triiodo-L-thyronineReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrix
prostaglandin H2Reach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Catalysed by COX10, COX15, PTGS1, PTGS2mitochondrial matrixOne of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX10, COX15, TBXAS1, PTGS2 and 1 moremitochondrial matrix
L-methionineReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by COX10, COX15, CDK5RAP1mitochondrial matrixOne of 4 routes
L-alanineReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by COX10, COX15, SCLYmitochondrial matrixOne of 2 routes
biliverdin IXalphaReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
3. Heme Oxygenase 1
Catalysed by COX10, HMOX1, HMOX2mitochondrial matrix, cytosolOne of 2 routes
3,4-dihydroxy-5-(all-trans-decaprenyl)benzoateReach from here →
1. decaprenyl diphosphate synthase (farnesyl-PP)
2. solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase
3. Hydroxylation of 3-Decaprenyl-4-Hydroxybenzoate (NADH)
Catalysed by PDSS1, PDSS2, COQ2cytosol, mitochondrial matrixOne of 3 routes
a 2,3-saturated acyl-CoAReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by COX10, COX15, ACAD10mitochondrial matrix
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by COX10, COX15, PTGS1, PTGS2mitochondrial matrix
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by COX10, COX15, PTGS1, PTGS2mitochondrial matrix
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
thio-Mo-molybdopterinReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by COX10, COX15, MOCOSmitochondrial matrix
ferroheme c di-L-cysteine(2-) residueReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate
3. Cytochrome c apocytochrome-c-lyase
Catalysed by COX10, HCCSmitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
prostaglandin H1Reach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by COX10, COX15, PTGS2mitochondrial matrix
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by COX10, COX15, PTGS1, PTGS2mitochondrial matrix