all-trans-retinol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

340 compounds within 3 steps: 18 in 1, 34 in 2, 288 in 3

Three steps

hexadecanedioyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. Production of Hexadecanedioylcarnitine
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 2 routes
(11Z,14Z)-eicosadienoateReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes
pristanoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. fatty-acid-CoA ligase
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 2 morecytosolOne of 2 routes
a 1,3-diacyl-sn-glycerolReach from here →
1. Lecithin Retinol Acyltransferase
2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)
Catalysed by LRAT, RPE65, ABHD11cytosol
a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholineReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 9 morecytosol
a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LRAT, ASPG, PLAAT1
undecanoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 7 morecytosolOne of 3 routes
a fatty acyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
3. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate
Catalysed by LRAT, RPE65, ACSL3cytosol
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS1 and 1 more
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS1 and 1 more
N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
1. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
2. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
Catalysed by PNPLA4, PNPLA2, DDHD2, PNLIPRP2 and 5 more
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes
N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)
Catalysed by LRAT, ASPG, PLAAT3, PLAAT1One of 3 routes
18-hydroxy-(9Z)-octadecenoateReach from here →
1. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
2. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PNPLA4, PNPLA2, DDHD2, PNLIPRP2 and 2 more
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
2. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)
Catalysed by PNPLA4, PNPLA2, DDHD2, PNLIPRP2 and 1 more
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
tricosanoateReach from here →
1. Lecithin Retinol Acyltransferase
2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
3. (10Z)-heptadecenoic acid formation
Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes
thio-Mo-molybdopterinReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, MOCOSOne of 3 routes
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by LRAT, ASPG, SGMS2One of 2 routes
(5Z)-tetradecenoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 5 morecytosol, mitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosol, mitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. Lecithin Retinol Acyltransferase
2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 4 routes
prostaglandin H1Reach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS2
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by RETSAT, AIFM1, PYROXD1, PTGS1 and 1 more