17beta-estradiol

Three steps

• estrone 3-O-(3-sulfo-beta-D-glucuronate)Reach from here →
  1. Estradiol-17beta:NADP+ 17-oxidoreductase
  2. UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
  3. estrone 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = estrone 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 7 morecytosol, endoplasmic reticulum

• butanoateReach from here →
  1. Estradiol-17beta:NADP+ 17-oxidoreductase
  2. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 7 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• glycocholateReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• adipic acidReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membrane

• pentanoateReach from here →
  1. Estradiol-17beta:NADP+ 17-oxidoreductase
  2. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
  3. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

  Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 7 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• taurocholateReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• glutaryl-CoAReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 17alpha-estradiol 3-O-(beta-D-glucuronate)Reach from here →
  1. Estradiol-17beta:NADP+ 17-oxidoreductase
  2. 17alpha-estradiol + NADP(+) = estrone + NADPH + H(+)
  3. 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)

  Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 13 morecytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• kynurenateReach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes