dihydroxyacetone

Three steps

• (2R)-3-phosphoglycerateReach from here →
  1. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate
  2. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate
  3. alpha-D-glucose 6-phosphate + (2R)-3-phospho-glyceroyl phosphate = alpha-D-glucose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)

  Catalysed by DCPH1, GPI, PGM2L1

• CDP-glycerolReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  3. CDPglycerol phosphoglycerohydrolase

  Catalysed by ALPL, ALPP, ALPI, ALPG and 3 moreextracellular space, cytosol

• an acyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ALPL, ALPP, ALPI, ALPG and 5 moreextracellular space, peroxisome, Golgi apparatusOne of 2 routes

• alpha-D-glucose 1,6-bisphosphateReach from here →
  1. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate
  2. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate
  3. alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate

  Catalysed by DCPH1, GPI, PGM1, PGM2One of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, mitochondrial matrixOne of 3 routes

• alpha-D-glucose 1-phosphateReach from here →
  1. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate
  2. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate
  3. alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate

  Catalysed by DCPH1, GPI, PGM1, PGM2

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 3 moreextracellular space, peroxisome, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 3 moreextracellular space, peroxisome, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 7 moreextracellular space, peroxisome, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 3 moreextracellular space, peroxisome, cytosol

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)
  2. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

  Catalysed by TKFC, TPI1, DERA

• CHEBI:63544Reach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 8 routes

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  3. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 6 moreextracellular space, cytosol

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 6 moreextracellular space, cytosol

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. Acyl-CoA:glycerone-phosphate O-acyltransferase
  3. alkylglycerone phosphate synthase (acylglycerone-phosphate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 2 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  3. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 6 moreextracellular space, cytosol

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 6 moreextracellular space, cytosol

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
  3. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 6 moreextracellular space, cytosol

• nonadecanoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, cytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Activation of dodecanedioic acid

  Catalysed by ALPL, ALPP, ALPI, ALPG and 1 moreextracellular space, peroxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Production of Sebacoylcarnitine

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Production of Suberylcarnitine

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ALPL, ALPP, ALPI, ALPG and 1 moreextracellular space, peroxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ALPL, ALPP, ALPI, ALPG and 4 moreextracellular space, peroxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. Glycerone phosphate phosphohydrolase
  2. glyceronephosphate O-acyltransferase (DHAP)
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ALPL, ALPP, ALPI, ALPG and 9 moreextracellular space, peroxisome, cytosolOne of 5 routes