1-acylglycerone 3-phosphate

Three steps

• 13-hydroxytetradecanoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. myristic acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 13-hydroxytetradecanoate[r]

  Catalysed by AGPS, CYP2E1peroxisome, extracellular space, endoplasmic reticulumOne of 3 routes

• (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

  Catalysed by AGPS, PTGS2peroxisome, extracellular space

• (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

  Catalysed by AGPS, PTGS2peroxisome, extracellular space

• prostaglandin G1Reach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

  Catalysed by AGPS, PTGS2peroxisome, extracellular space

• prostaglandin G3Reach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3

  Catalysed by AGPS, PTGS2peroxisome, extracellular space

• 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP3A4, CYP2C9peroxisome, extracellular space

• (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

  Catalysed by AGPS, ALOX5, ALOX15peroxisome, extracellular space

• 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate

  Catalysed by AGPS, ALOX15peroxisome, extracellular space

• (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

  Catalysed by AGPS, ALOX15peroxisome, extracellular space

• (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

  Catalysed by AGPS, ALOX15peroxisome, extracellular space

• 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP4F8, CYP4F12peroxisome, extracellular space

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by AGPS, SLCO1B1peroxisome, extracellular space, cytosolOne of 2 routes

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by AGPS, PM20D1peroxisome, extracellular space

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by AGPS, PM20D1peroxisome, extracellular space

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by AGPS, PM20D1peroxisome, extracellular space

• (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP1A1, CYP1A2, CYP3A4 and 4 moreperoxisome, extracellular space

• (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP1A1, CYP3A4, CYP2C8 and 3 moreperoxisome, extracellular space

• 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP2C9peroxisome, extracellular space

• 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP2C8, CYP2C9peroxisome, extracellular space

• 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP2C8, CYP2C9peroxisome, extracellular space

• 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. unspecific monooxygenase (arachidonate)

  Catalysed by AGPS, CYP1A1, CYP1A2, CYP2E1 and 23 moreperoxisome, extracellular space, cytosolOne of 2 routes

• 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. unspecific monooxygenase (arachidonate)

  Catalysed by AGPS, CYP1A1, CYP1A2, CYP2E1 and 23 moreperoxisome, extracellular space, cytosolOne of 2 routes

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPS, CYP2C9peroxisome, extracellular space

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. unspecific monooxygenase (arachidonate)

  Catalysed by AGPS, CYP1A1, CYP1A2, CYP2E1 and 23 moreperoxisome, extracellular space, cytosol

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by AGPSperoxisome, extracellular space, cytosolOne of 2 routes

• 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerolReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)

  Catalysed by AGPS, DAGLBperoxisome, extracellular space

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by AGPS, FAAH, PM20D1peroxisome, extracellular space

• (7Z)-octadecenoyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 3 routes

• CHEBI:15345Reach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 7 morecytosol, mitochondrial matrixOne of 2 routes

• cholineReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 7 morecytosol, mitochondrial matrix, nucleus

• CHEBI:15380Reach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 8 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• isobutyryl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 7 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 14 morecytosol, mitochondrial matrixOne of 14 routes

• CHEBI:15519Reach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 14 morecytosol, mitochondrial matrixOne of 14 routes

• oleoyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 14 routes

• phenylacetyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 3 routes

• propionyl-CoAReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by AKR1A1, AGPAT2, LCLAT1, MBOAT1 and 9 morecytosol, mitochondrial matrixOne of 43 routes

• (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. alkylglycerone phosphate synthase (acylglycerone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by AGPS, ALOX5peroxisome, extracellular space