Skip to content
Catalyst

L-isoleucineFinding

L-isoleucine activates ACSL4

raisesInsufficient evidenceFinding

01 · The sentence it was drawn from

“Isoleucine exposure induced hyperacetylation of H3K9 (histone H3 lysine 9) within the ACSL4 promoter, thereby activating transcription of this ferroptosis-associated gene (Figure and).”
Quoted verbatim from Fusobacterium nucleatum-Derived Isoleucine Exacerbates Aneurysm by Inducing Ferroptosis in Vascular Smooth Muscle Cells.
This finding among the 1 finding on its endpoint

L-isoleucine

ACSL4

activates

Who
human aortic smooth muscle cells (HASMCs) exposed to 10 mmol/L isoleucine
Dose studied
10 mmol/L isoleucine in serum-free smooth muscle cell medium

Insufficient evidencePMID 42206370 · 2026

02 · The study

Study
in vitro · not in humans
Duration
not reported

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

Arteriosclerosis, thrombosis, and vascular biology
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZVEEE2CHC10EPXTSWDA1GE