L-isoleucine/Finding
One finding, on its own
A single claim from the graph, with the grade computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Decreases alanine aminotransferase
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.”
Quoted verbatim from Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.. - Study
- animal · not in humans
- Participants
- 15
- Duration
- 3 months
- Dose
- 3% (w/w) isoleucine added to fast-food diet for 12 weeks
- Population
- Male Ldlr-/-.Leiden mice with fast-food-diet-induced obesity and NASH, 12-week dietary isoleucine (3% w/w) supplementation after a 26-week fast-food-diet run-in
Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.2022PMID:35830259Permalink
Keep reading
- Everything the graph holds on L-isoleucine
- Every compound studied against Alanine aminotransferase
- How to read the grade and the marks
To cite this finding: https://catalystproject.ai/e/01M3PA2HBQNWE8K3BERPNSZYCA