Papers/PMID:35830259
Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology2022The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-isoleucine — decreases alanine aminotransferase
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Isoleucine had a more pronounced lowering effect and significantly decreased ALT and CK18‐M30.”
Quoted verbatim from Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.. - Study
- animal · not in humans
- Participants
- 15
- Duration
- 3 months
- Dose
- 3% (w/w) isoleucine added to fast-food diet for 12 weeks
- Population
- Male Ldlr-/-.Leiden mice with fast-food-diet-induced obesity and NASH, 12-week dietary isoleucine (3% w/w) supplementation after a 26-week fast-food-diet run-in
Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH.2022PMID:35830259Permalink