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PapersPMID:42206370

Fusobacterium nucleatum-Derived Isoleucine Exacerbates Aneurysm by Inducing Ferroptosis in Vascular Smooth Muscle Cells.

Arteriosclerosis, thrombosis, and vascular biology2026The record ↗

  1. Finding, insufficient evidenceraisesACSL4

What moved

1 findingHow to read these marks →
  • Activates ACSL4

    insufficient

    “Isoleucine exposure induced hyperacetylation of H3K9 (histone H3 lysine 9) within the ACSL4 promoter, thereby activating transcription of this ferroptosis-associated gene (Figure and).”
    Study
    in vitro · not in humans
    Dose studied
    10 mmol/L isoleucine in serum-free smooth muscle cell medium
    Population
    human aortic smooth muscle cells (HASMCs) exposed to 10 mmol/L isoleucine

Study record

Design
animal study, in vivo / mechanistic study
Species
mixed
Population
Patients with abdominal aortic aneurysm (AAA) and matched healthy controls (dental plaque, plasma, aortic tissue); male ApoE-/- C57BL/6J mice with AngII-induced AAA; human aortic smooth muscle cells (HASMCs); Fusobacterium nucleatum cultures. L-isoleucine used as 10 mmol/L in cells and as dietary L-isoleucine in mice.
Participants
not reported
Comparator
not stated in the paper / placebo
Duration
28 days
Endpoints measured
33