Proteins/UNIPROT:P48059

LIMS1

ProteinUNIPROT:P48059

Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration..

Function from UniProtKB (P48059), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

35 statements

35 statements · 4 reference databases · Subject: LIMS1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

LIMS1 covaries with KRT77ProteinHetionet hetionet:covaries:374454-3987Inferred only
LIMS1 interacts with ADAMTS9ProteinHetionet hetionet:interacts:3987-56999Inferred only
LIMS1 interacts with ATXN10ProteinHetionet hetionet:interacts:25814-3987Inferred only
LIMS1 interacts with CSRP3ProteinHetionet hetionet:interacts:3987-8048Inferred only
LIMS1 interacts with EHMT2ProteinHetionet hetionet:interacts:10919-3987Inferred only
FMR1 interacts with LIMS1ProteinHetionet hetionet:interacts:2332-3987Inferred only
ILK interacts with LIMS1ProteinHetionet hetionet:interacts:3611-3987Inferred only
LIMS1 interacts with IPO7ProteinHetionet hetionet:interacts:10527-3987Inferred only
LIMS1 interacts with LPXNProteinHetionet hetionet:interacts:3987-9404Inferred only
LIMS1 interacts with MBIPProteinHetionet hetionet:interacts:3987-51562Inferred only
LIMS1 interacts with NCK2ProteinHetionet hetionet:interacts:3987-8440Inferred only
LIMS1 interacts with OSR2ProteinHetionet hetionet:interacts:116039-3987Inferred only

Show the remaining 23

LIMS1 interacts with PEG3ProteinHetionet hetionet:interacts:3987-5178Inferred only
LIMS1 interacts with PLCE1ProteinHetionet hetionet:interacts:3987-51196Inferred only
LIMS1 interacts with RBBP8ProteinHetionet hetionet:interacts:3987-5932Inferred only
LIMS1 interacts with RSU1ProteinHetionet hetionet:interacts:3987-6251Inferred only
LIMS1 interacts with SMURF1ProteinHetionet hetionet:interacts:3987-57154Inferred only
LIMS1 interacts with STUB1ProteinHetionet hetionet:interacts:10273-3987Inferred only
LIMS1 interacts with TGFBR1ProteinHetionet hetionet:interacts:3987-7046Inferred only
LIMS1 interacts with TMSB4XProteinHetionet hetionet:interacts:3987-7114Inferred only
LIMS1 interacts with TRIOProteinHetionet hetionet:interacts:3987-7204Inferred only
LIMS1 interacts with TTNProteinHetionet hetionet:interacts:3987-7273Inferred only
LIMS1 interacts with UBCProteinHetionet hetionet:interacts:3987-7316Inferred only
LIMS1 interacts with USP11ProteinHetionet hetionet:interacts:3987-8237Inferred only
LIMS1 interacts with ZMYM4ProteinHetionet hetionet:interacts:3987-9202Inferred only
LIMS1 interacts with ZNF160ProteinHetionet hetionet:interacts:3987-90338Inferred only
LIMS1 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
LIMS1 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
LIMS1 participates in Cell-extracellular matrix interactionsPathwayReactome R-HSA-446353Inferred only
LIMS1 participates in Primary focal segmental glomerulosclerosis FSGS PathwayWikiPathways WP2572Inferred only
LIMS1 participates in Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsPathwayReactome R-HSA-446388Inferred only
LIMS1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology P48059|GO:0045892Inferred only
LIMS1 regulates positive regulation of canonical NF-kappaB signal transductionBiological processgene ontology P48059|GO:0043123Inferred only
LIMS1 regulates positive regulation of integrin-mediated signaling pathwayBiological processgene ontology P48059|GO:2001046Inferred only
RORC decreases the expression of LIMS1ProteinHetionet hetionet:regulates:6097-3987Inferred only

Other names

5 names

Resolves to: LIMS1

Also called: Particularly interesting new Cys-His protein 1PINCHPINCH-1PINCH1Renal carcinoma antigen NY-REN-48

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