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Proteins/UNIPROT:O95425
[Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts..
[Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity)..
Function from UniProtKB (O95425), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
41 statements
41 statements · 2 reference databases · Subject: SVIL · Sources: gene ontology, Hetionet
2 names
Resolves to: SVIL