Pathway
Insulin effects increased synthesis of Xylulose-5-Phosphate
One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A.
REACT:R-HSA-163754Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: Insulin effects increased synthesis of Xylulose-5-Phosphate · Sources: Reactome
- TALDO1 participates in Insulin effects increased synthesis of Xylulose-5-PhosphateProteinReactome R-HSA-163754Inferred only
- TKT participates in Insulin effects increased synthesis of Xylulose-5-PhosphateProteinReactome R-HSA-163754Inferred only