Proteins/UNIPROT:Q8NFH8

REPS2

ProteinUNIPROT:Q8NFH8

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway. By controlling growth factor receptors endocytosis may regulate cell survival. Through ASAP1 may regulate cell adhesion and migration..

Function from UniProtKB (Q8NFH8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

complex neurodevelopmental disorder has a germline basis in REPS2DiseaseGenCC HGNC:9963|MONDO:0100038Inferred only

Statements

24 statements

24 statements · 3 reference databases · Subject: REPS2 · Sources: Hetionet, Reactome, WikiPathways

Order

REPS2 covaries with CENPBProteinHetionet hetionet:covaries:1059-9185Inferred only
REPS2 covaries with ZNF354BProteinHetionet hetionet:covaries:117608-9185Inferred only
ZNF655 covaries with REPS2ProteinHetionet hetionet:covaries:79027-9185Inferred only
AMPH interacts with REPS2ProteinHetionet hetionet:interacts:273-9185Inferred only
AR interacts with REPS2ProteinHetionet hetionet:interacts:367-9185Inferred only
REPS2 interacts with ASAP1ProteinHetionet hetionet:interacts:50807-9185Inferred only
ASAP2 interacts with REPS2ProteinHetionet hetionet:interacts:8853-9185Inferred only
CDK1 interacts with REPS2ProteinHetionet hetionet:interacts:9185-983Inferred only
REPS2 interacts with CDK5RAP2ProteinHetionet hetionet:interacts:55755-9185Inferred only
REPS2 interacts with EPN1ProteinHetionet hetionet:interacts:29924-9185Inferred only
EPS15 interacts with REPS2ProteinHetionet hetionet:interacts:2060-9185Inferred only
GRB2 interacts with REPS2ProteinHetionet hetionet:interacts:2885-9185Inferred only

Show the remaining 12

PXN interacts with REPS2ProteinHetionet hetionet:interacts:5829-9185Inferred only
RALB interacts with REPS2ProteinHetionet hetionet:interacts:5899-9185Inferred only
REPS2 interacts with RALBP1ProteinHetionet hetionet:interacts:10928-9185Inferred only
RELA interacts with REPS2ProteinHetionet hetionet:interacts:5970-9185Inferred only
REPS2 interacts with REPS1ProteinHetionet hetionet:interacts:85021-9185Inferred only
REPS2 interacts with TRAPPC2LProteinHetionet hetionet:interacts:51693-9185Inferred only
REPS2 participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
REPS2 participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
REPS2 participates in EGF EGFR signalingPathwayWikiPathways WP437Inferred only
REPS2 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
REPS2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
RAB4A increases the expression of REPS2ProteinHetionet hetionet:regulates:5867-9185Inferred only

Other names

3 names

Resolves to: REPS2

Also called: Partner of RalBP1POB1RalBP1-interacting protein 2

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