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Proteins/UNIPROT:O95255
[Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin..
[Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis..
[Isoform 2]: Inhibits TNF-mediated apoptosis through blocking one or more caspases..
Function from UniProtKB (O95255), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
26 statements
26 statements · 6 reference databases · Subject: ABCC6 · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
an S-substituted glutathione+ATP(4-)+wateran S-substituted glutathione+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC3 or ABCC4 or ABCC6 or ABCC1 or RALBP1 or ABCC10 or ABCC2 or ABCC11
Reaction pageLeft to rightBalance undeterminable
6 names
Resolves to: ABCC6
leukotriene C4+ATP(4-)+waterleukotriene C4+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC3 or ABCC4 or ABCC6 or ABCC1 or RALBP1 or ABCC10 or ABCC2 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:38963CC BY 4.0Reference data