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Proteins/UNIPROT:Q8N8N7
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)..
Function from UniProtKB (Q8N8N7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 4 reference databases · Subject: PTGR2 · Sources: Hetionet, Reactome, Rhea, WikiPathways
5 reactions
13,14-dihydro-15-oxo-prostaglandin E2+NADP(3-)15-oxoprostaglandin E2+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:11912CC BY 4.0Reference data
13,14-dihydro-15-oxo-prostaglandin E2+NAD(1-)15-oxoprostaglandin E2+NADH(2-)+
4 names
Resolves to: PTGR2
Catalysed by PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:11916CC BY 4.0Reference data
CHEBI:133408+NADP(3-)15-oxoprostaglandin E1+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50584CC BY 4.0Reference data
CHEBI:133374+NADP(3-)15-oxoprostaglandin F2alpha+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50588CC BY 4.0Reference data
CHEBI:133411+NADP(3-)CHEBI:79072+NADPH(4-)+hydron
Catalysed by PTGR1 or PTGR3 or PTGR2
Reaction pageRight to leftBalanced
Rhea RHEA:50592CC BY 4.0Reference data