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Proteins/UNIPROT:P53708

ITGA8

Protein·UNIPROT:P53708

Open in the graph

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons..

Function from UniProtKB (P53708), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

bilateral renal agenesis has a germline basis in ITGA8DiseaseGenCC HGNC:6144|MONDO:0015986Inferred only
renal hypodysplasia/aplasia 1 has a germline basis in ITGA8DiseaseGenCC HGNC:6144|MONDO:0024519Inferred only

Statements

40 statements

40 statements · 4 reference databases · Subject: ITGA8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

BTN2A2 covaries with ITGA8ProteinHetionet hetionet:covaries:10385-8516Inferred only
CACUL1 covaries with ITGA8ProteinHetionet hetionet:covaries:143384-8516Inferred only
FREM2 covaries with ITGA8ProteinHetionet hetionet:covaries:341640-8516Inferred only
FZD3 covaries with ITGA8ProteinHetionet hetionet:covaries:7976-8516Inferred only
GAL3ST2 covaries with ITGA8ProteinHetionet hetionet:covaries:64090-8516Inferred only
ITGA8 covaries with KPRPProteinHetionet hetionet:covaries:448834-8516Inferred only
MPG covaries with ITGA8ProteinHetionet hetionet:covaries:4350-8516Inferred only
NTF4 covaries with ITGA8ProteinHetionet hetionet:covaries:4909-8516Inferred only
OPN1LW covaries with ITGA8ProteinHetionet hetionet:covaries:5956-8516Inferred only
PTGR3 covaries with ITGA8ProteinHetionet hetionet:covaries:284273-8516Inferred only
RHBDL1 covaries with ITGA8ProteinHetionet hetionet:covaries:8516-9028Inferred only
SLC12A9 covaries with ITGA8ProteinHetionet hetionet:covaries:56996-8516Inferred only

Show the remaining 28

SOX4 covaries with ITGA8ProteinHetionet hetionet:covaries:6659-8516Inferred only
TMUB1 covaries with ITGA8ProteinHetionet hetionet:covaries:83590-8516Inferred only
XKR6 covaries with ITGA8ProteinHetionet hetionet:covaries:286046-8516Inferred only
FN1 interacts with ITGA8ProteinHetionet hetionet:interacts:2335-8516Inferred only
ITGA8 interacts with NPNTProteinHetionet hetionet:interacts:255743-8516Inferred only
UBC interacts with ITGA8ProteinHetionet hetionet:interacts:7316-8516Inferred only
VTN interacts with ITGA8ProteinHetionet hetionet:interacts:7448-8516Inferred only
ITGA8 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
ITGA8 participates in Development of ureteric derived collecting systemPathwayWikiPathways WP5053Inferred only
ITGA8 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ITGA8 participates in ECM proteoglycansPathwayReactome R-HSA-3000178Inferred only
ITGA8 participates in Elastic fibre formationPathwayReactome R-HSA-1566948Inferred only
ITGA8 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ITGA8 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
ITGA8 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
ITGA8 participates in Formation of the ureteric budPathwayReactome R-HSA-9830674Inferred only
ITGA8 participates in Genes controlling nephrogenesisPathwayWikiPathways WP4823Inferred only
ITGA8 participates in Hippo Merlin signaling dysregulationPathwayWikiPathways WP4541Inferred only
ITGA8 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only
ITGA8 participates in Integrin mediated cell adhesionPathwayWikiPathways WP185Inferred only
ITGA8 participates in Kidney developmentPathwayReactome R-HSA-9830369Inferred only
ITGA8 participates in Molecules associated with elastic fibresPathwayReactome R-HSA-2129379Inferred only
ITGA8 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
ITGA8 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ITGA8 participates in Signaling by TGF-beta Receptor ComplexPathwayReactome R-HSA-170834Inferred only
ITGA8 participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
ITGA8 participates in TGF-beta receptor signaling activates SMADsPathwayReactome R-HSA-2173789Inferred only
ITGA8 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P53708|GO:0045944Inferred only

Other names

1 name

Resolves to: ITGA8

Also called: Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

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