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Proteins/UNIPROT:Q9UJU5

FOXD3

Protein·UNIPROT:Q9UJU5

Open in the graph

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Negatively regulates transcription of transcriptional repressor RHIT/ZNF205. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis..

Function from UniProtKB (Q9UJU5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

12 statements

12 statements · 4 reference databases · Subject: FOXD3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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POU5F1 interacts with FOXD3ProteinHetionet hetionet:interacts:27022-5460Inferred only
FOXD3 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
FOXD3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
FOXD3 participates in MITF-M-regulated melanocyte developmentPathwayReactome R-HSA-9730414Inferred only
FOXD3 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
FOXD3 participates in POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationPathwayReactome R-HSA-2892247Inferred only
FOXD3 participates in Transcriptional and post-translational regulation of MITF-M expression and activityPathwayReactome R-HSA-9856649Inferred only
FOXD3 participates in Transcriptional regulation of pluripotent stem cellsPathwayReactome R-HSA-452723Inferred only
FOXD3 participates in Wnt signaling and pluripotencyPathwayWikiPathways WP399Inferred only
FOXD3 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UJU5|GO:0000122Inferred only
FOXD3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UJU5|GO:0045944Inferred only
FOXD3 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UJU5|GO:0006357Inferred only

Other names

3 names

Resolves to: FOXD3

Also called: Forkhead box protein D3HFH2HNF3/FH transcription factor genesis

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