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Proteins/UNIPROT:Q16348
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs. Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine. Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand..
Function from UniProtKB (Q16348), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
266 statements
266 statements · 6 reference databases · Subject: SLC15A2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Rhea, WikiPathways
251 reactions
L-cysteinylglycine+2protonL-cysteinylglycine+2proton
Transported by SLC15A1 or SLC15A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07680CC BY 4.0Reference data
proton+MAM03411eproton+MAM03411c
4 names
Resolves to: SLC15A2
Human-GEM MAR10739CC BY 4.0Reference data
proton+MAM03412eproton+MAM03412c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10740CC BY 4.0Reference data
proton+MAM03413eproton+MAM03413c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10741CC BY 4.0Reference data
proton+MAM03414eproton+MAM03414c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10742CC BY 4.0Reference data
proton+MAM03415eproton+MAM03415c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10743CC BY 4.0Reference data
proton+MAM03416eproton+MAM03416c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10744CC BY 4.0Reference data
proton+MAM03435eproton+MAM03435c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10745CC BY 4.0Reference data
proton+MAM03436eproton+MAM03436c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10746CC BY 4.0Reference data
proton+MAM03437eproton+MAM03437c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10747CC BY 4.0Reference data
proton+MAM03438eproton+MAM03438c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10748CC BY 4.0Reference data
proton+MAM03439eproton+MAM03439c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10749CC BY 4.0Reference data