Proteins/UNIPROT:Q9BYZ6

RHOBTB2

ProteinUNIPROT:Q9BYZ6

Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation..

Function from UniProtKB (Q9BYZ6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder has a germline basis in RHOBTB2DiseaseGenCC HGNC:18756|MONDO:0100038Inferred only
developmental and epileptic encephalopathy, 64 has a germline basis in RHOBTB2DiseaseGenCC HGNC:18756|MONDO:0033373Inferred only

Statements

22 statements

22 statements · 5 reference databases · Subject: RHOBTB2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Order

PNPLA4 covaries with RHOBTB2ProteinHetionet hetionet:covaries:23221-8228Inferred only
RHOBTB2 covaries with SSNA1ProteinHetionet hetionet:covaries:23221-8636Inferred only
TGIF2 covaries with RHOBTB2ProteinHetionet hetionet:covaries:23221-60436Inferred only
CUL3 interacts with RHOBTB2ProteinHetionet hetionet:interacts:23221-8452Inferred only
CUL5 interacts with RHOBTB2ProteinHetionet hetionet:interacts:23221-8065Inferred only
RHOBTB3 interacts with RHOBTB2ProteinHetionet hetionet:interacts:22836-23221Inferred only
RHOBTB2 participates in Rett syndromePathwayWikiPathways WP4312Inferred only
RHOBTB2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
RHOBTB2 participates in RHOBTB GTPase CyclePathwayReactome R-HSA-9706574Inferred only
RHOBTB2 participates in RHOBTB2 GTPase cyclePathwayReactome R-HSA-9013418Inferred only
RHOBTB2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RHOBTB2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only

Show the remaining 10

RHOBTB2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
RHOBTB2 regulates regulation of cell shapeBiological processgene ontology Q9BYZ6|GO:0008360Inferred only
RHOBTB2 decreases the expression of CDC25BProteinHetionet hetionet:regulates:23221-994Inferred only
RHOBTB2 increases the expression of COL11A1ProteinHetionet hetionet:regulates:23221-1301Inferred only
RHOBTB2 decreases the expression of FABP5ProteinHetionet hetionet:regulates:23221-2171Inferred only
RHOBTB2 increases the expression of FZD7ProteinHetionet hetionet:regulates:23221-8324Inferred only
RHOBTB2 increases the expression of RPL39LProteinHetionet hetionet:regulates:23221-116832Inferred only
RHOBTB2 decreases the expression of TNFRSF21ProteinHetionet hetionet:regulates:23221-27242Inferred only
RHOBTB2 increases the expression of UBQLN2ProteinHetionet hetionet:regulates:23221-29978Inferred only
RHOBTB2 requires the cofactor magnesium(2+)CompoundUniProt Q9BYZ6Inferred only

Reactions

1 reaction

GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction page

Other names

4 names

Resolves to: RHOBTB2

Also called: DBC2Deleted in breast cancer 2 gene proteinKIAA0717p83

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