CHD6, CHD7, CHD8, CHD9 subfamily

CHD6, CHD7, CHD8 and CHD9 make up subfamily III, based on their orthology to the founding member in Drosophila, Kismet. Like subfamily I and II proteins, subfamily III proteins have tandem N-terminal chromodomains and a SNF2 ATPase domain, but also have additional C-terminal motifs including a Brahma-Kismet (BRK) domain, a SANT motif, and a DNA-binding region (reviewed in Marfella and Imbalzano, 2007; Alendar and Berns, 2021). The function of the BRK domain, so named because of its identification in the Drosophila Brahma and Kismet proteins, is not elucidated but it may play a role in binding CTCF. Like other CHD proteins, subfamily III is implicated in regulation of transcription, proliferation and repair of DNA damage (reviewed in Alendar and Berns, 2021). Although CHD6-9 are 50-54% identical, they appear to have distinct biochemical characteristics and to play non-redundant biological roles (Manning and Yusufzai, 2017; reviewed in Mills et al, 2017).

Summary from Reactome (R-HSA-9943962), read 2026-09-23.