Pathway
Meiosis
During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired by synapsis along their regions of homologous DNA, and then segregated, resulting in haploid daughters containing sister chromatids paired at their centromeres. The sister chromatids are then separated and segregated during meiosis II.
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Recombination between chromosomal homologues but not between sister chromatids occurs during prophase of meiosis I. Though hundreds of recombination events are initiated, most are resolved without crossovers and only tens proceed to become crossovers. In mammals recombination events are required between homologues for normal pairing, synapsis, and segregation.
What the reference databases state
Statements
84 statements
84 statements · 1 reference database · Subject: Meiosis · Sources: Reactome
- ACD participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- ATM participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- ATR participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- BLM participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- BRCA1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- BRCA2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- CDK2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- CDK4 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- DMC1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- FIGNL1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- FIRRM participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- FKBP6 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
Show the remaining 72
- H2AB1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AC14 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AC18; H2AC19 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AC20 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AC4; H2AC8 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AC6 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AC7 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AJ participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AX participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2AZ2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC11 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC12 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC13 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC14 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC15 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC17 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC21 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC26 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H2BC9 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H3-3A; H3-3B participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H3-4 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H3C15; H3C14; H3C13 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- HSPA2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- LMNB1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- MLH1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- MLH3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- MND1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- MRE11 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- MSH4 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- MSH5 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- NBN participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- POT1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- PRDM9 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- PSMC3IP participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RAD21 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RAD50 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RAD51 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RAD51C participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RBBP8 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- REC8 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RPA1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RPA2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- RPA3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SMC1A participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SMC1B participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SMC3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SPO11 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- STAG1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- STAG2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- STAG3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SUN1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SUN2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYCE1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYCE2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYCE3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYCP1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYCP2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYCP3 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYNE1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- SYNE2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- TERF1 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- TERF2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- TERF2IP participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- TEX12 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- TINF2 participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- TOP3A participates in MeiosisProteinReactome R-HSA-1500620Inferred only
- UBE2I participates in MeiosisProteinReactome R-HSA-1500620Inferred only