Pathway
RUNX1 regulates transcription of genes involved in differentiation of HSCs
The RUNX1:CBFB complex regulates transcription of the SPI1 (PU.1) gene, involved in differentiation of hematopoietic stem cells (HSCs). RUNX1 recruits histone methyltransferase KMT2A (MLL) to the SPI1 gene locus, leading to generation of the activating H3K4Me3 mark on nucleosomes associated with the SPI1 promoter and the upstream regulatory element. SPI1 transactivation represses self-renewal and proliferation of HSCs and is needed for commitment of HSCs to specific hematopoietic lineages.
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As a component of the TAL1 transcription factor complex, involved in acute T cell lymphoblastic leukemia (T-ALL), RUNX1 can promote growth and inhibit apoptosis of hematopoietic stem cells by stimulating transcription of the MYB gene and possibly the TRIB2 gene.
REACT:R-HSA-8939236Reactome
What the reference databases state
Statements
83 statements
83 statements · 1 reference database · Subject: RUNX1 regulates transcription of genes involved in differentiation of HSCs · Sources: Reactome
- ABL1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- ADRM1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- CBFB participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- CCNH participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- CDK7 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- GATA1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- GATA2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- GATA3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AB1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AC14 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AC18; H2AC19 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AC20 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
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- H2AC4; H2AC8 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AC6 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AC7 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AJ participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AX participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2AZ2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC11 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC12 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC13 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC14 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC15 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC17 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC21 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC26 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H2BC9 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H3-3A; H3-3B participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H3C15; H3C14; H3C13 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- ITCH participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- KMT2A participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- LDB1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- LMO1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- LMO2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- MNAT1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- MYB participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA4 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA5 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA6 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMA7 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB4 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB5 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB6 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMB7 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMC1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMC2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMC3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMC4 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMC5 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMC6 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD11 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD12 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD13 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD14 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD2 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD6 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD7 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- PSMD8 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- RPS27A participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- RUNX1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- SEM1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- SPI1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- TAL1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- TCF12 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- TCF3 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- TP73 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- UBA52 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- UBB participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- UBC participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only
- YAP1 participates in RUNX1 regulates transcription of genes involved in differentiation of HSCsProteinReactome R-HSA-8939236Inferred only