Pathway
Condensation of Prophase Chromosomes
In mitotic prophase, the action of the condensin II complex enables initial chromosome condensation.
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The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associating with chromatin. Binding of the condensin II complex to chromatin is partially controlled by the presence of RB1.
Two mechanisms contribute to the accumulation of H4K20me1 at mitotic entry. First, the activity of SETD8 histone methyltransferase peaks at G2/M transition. Second, the complex of CDK1 and cyclin B1 (CDK1:CCNB1) phosphorylates PHF8 histone demethylase at the start of mitosis, removing it from chromatin.
Condensin II complex needs to be phosphorylated by the CDK1:CCNB1 complex, and then phosphorylated by PLK1, in order to efficiently condense prophase chromosomes.
REACT:R-HSA-2299718Reactome
What the reference databases state
Statements
39 statements
39 statements · 1 reference database · Subject: Condensation of Prophase Chromosomes · Sources: Reactome
- CCNB1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- CDK1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AB1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AC14 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AC18; H2AC19 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AC20 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AC4; H2AC8 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AC6 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AC7 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AJ participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AX participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2AZ2 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
Show the remaining 27
- H2BC1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC11 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC12 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC13 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC14 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC15 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC17 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC21 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC26 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC3 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H2BC9 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H3-3A; H3-3B participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H3-4 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H3C15; H3C14; H3C13 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- KMT5A participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- MCPH1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- NCAPD3 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- NCAPG2 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- NCAPH2 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- PLK1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- RB1 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- SET participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- SMC2 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only
- SMC4 participates in Condensation of Prophase ChromosomesProteinReactome R-HSA-2299718Inferred only