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Proteins/UNIPROT:Q9H5K3
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif..
Function from UniProtKB (Q9H5K3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
16 statements
16 statements · 2 reference databases · Subject: POMK · Sources: Hetionet, Reactome
1 reaction
3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein]+ATP(4-)3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein]+ADP(3-)+hydron
Catalysed by POMK
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52616CC BY 4.0Reference data
4 names
Resolves to: POMK