Proteins/UNIPROT:Q8N6C5

IGSF1

ProteinUNIPROT:Q8N6C5

Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription..

Function from UniProtKB (Q8N6C5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

X-linked central congenital hypothyroidism with late-onset testicular enlargement has a germline basis in IGSF1DiseaseGenCC HGNC:5948|MONDO:0010475Inferred only

Statements

14 statements

14 statements · 2 reference databases · Subject: IGSF1 · Sources: gene ontology, Hetionet

Order

IGSF1 covaries with ADAMTS9ProteinHetionet hetionet:covaries:3547-56999Inferred only
ACVR1 interacts with IGSF1ProteinHetionet hetionet:interacts:3547-90Inferred only
ACVR1B interacts with IGSF1ProteinHetionet hetionet:interacts:3547-91Inferred only
ACVR2A interacts with IGSF1ProteinHetionet hetionet:interacts:3547-92Inferred only
ACVR2B interacts with IGSF1ProteinHetionet hetionet:interacts:3547-93Inferred only
ACVRL1 interacts with IGSF1ProteinHetionet hetionet:interacts:3547-94Inferred only
BMPR1A interacts with IGSF1ProteinHetionet hetionet:interacts:3547-657Inferred only
BMPR1B interacts with IGSF1ProteinHetionet hetionet:interacts:3547-658Inferred only
IGSF1 interacts with HECTD1ProteinHetionet hetionet:interacts:25831-3547Inferred only
IGF1 interacts with IGSF1ProteinHetionet hetionet:interacts:3479-3547Inferred only
IGSF1 interacts with INHBBProteinHetionet hetionet:interacts:3547-3625Inferred only
IGSF1 interacts with RANBP10ProteinHetionet hetionet:interacts:3547-57610Inferred only

Show the remaining 2

IGSF1 regulates negative regulation of activin receptor signaling pathwayBiological processgene ontology Q8N6C5|GO:0032926Inferred only
IGSF1 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q8N6C5|GO:0006355Inferred only

Other names

8 names

Resolves to: IGSF1

Also called: IGDC1Immunoglobulin-like domain-containing protein 1InhBPInhibin-binding proteinKIAA0364p120PGSF2Pituitary gland-specific factor 2

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