primary ovarian failure
MONDO:0005387Mondo
Findings
No curated finding names primary ovarian failure yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.
Definition from the Mondo Disease Ontology (MONDO:0005387), read 2026-09-29. CC BY 4.0.
Genes
19 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- DMC1HGNC:2927
- Strong · PanelApp Australia · Autosomal recessive · 2025
- KHDRBS1HGNC:18116
- Strong · PanelApp Australia · Autosomal dominant · 2025
- PRDM9HGNC:13994
- Strong · PanelApp Australia · Autosomal dominant · 2025
- BMPR1AHGNC:1076
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- BUB1BHGNC:1149
- Moderate · PanelApp Australia · Autosomal recessive · 2025
- DAZLHGNC:2685
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- EIF4ENIF1HGNC:16687
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- FANCIHGNC:25568
- Moderate · PanelApp Australia · Autosomal recessive · 2025
- HELQHGNC:18536
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- NANOS3HGNC:22048
- Moderate · PanelApp Australia · Semidominant · 2025
- POLR2CHGNC:9189
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- POLR3HHGNC:30349
- Moderate · PanelApp Australia · Autosomal recessive · 2025
- REC8HGNC:16879
- Moderate · PanelApp Australia · Autosomal recessive · 2025
- ZNF483HGNC:23384
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- BMPR2HGNC:1078
- Limited · PanelApp Australia · Autosomal dominant · 2025
- DACH2HGNC:16814
- Limited · PanelApp Australia · Autosomal dominant · 2025
- PGRMC1HGNC:16090
- Limited · PanelApp Australia · Autosomal dominant · 2025
- POU5F1HGNC:9221
- Limited · PanelApp Australia · Autosomal dominant · 2025
- RAD51BHGNC:9822
- Limited · Ambry Genetics · Autosomal recessive · 2024
Where it sits
- A kind of