Proteins/UNIPROT:Q9HBG6

IFT122

ProteinUNIPROT:Q9HBG6

As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning (By similarity)..

Function from UniProtKB (Q9HBG6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

cranioectodermal dysplasia has a germline basis in IFT122DiseaseGenCC HGNC:13556|MONDO:0009032Inferred only
cranioectodermal dysplasia 1 has a germline basis in IFT122DiseaseGenCC HGNC:13556|MONDO:0021093Inferred only

Statements

20 statements

20 statements · 4 reference databases · Subject: IFT122 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

IFT122 covaries with C12orf71ProteinHetionet hetionet:covaries:55764-728858Inferred only
UBC interacts with IFT122ProteinHetionet hetionet:interacts:55764-7316Inferred only
IFT122 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
IFT122 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
IFT122 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
IFT122 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
IFT122 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
IFT122 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
IFT122 participates in Hedgehog 'off' statePathwayReactome R-HSA-5610787Inferred only
IFT122 participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only
IFT122 participates in Intraflagellar transport proteins binding to dyneinPathwayWikiPathways WP4532Inferred only
IFT122 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only

Show the remaining 8

IFT122 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
IFT122 participates in Signaling by HedgehogPathwayReactome R-HSA-5358351Inferred only
IFT122 regulates negative regulation of smoothened signaling pathwayBiological processgene ontology Q9HBG6|GO:0045879Inferred only
BCL7B increases the expression of IFT122ProteinHetionet hetionet:regulates:9275-55764Inferred only
DNAJB9 increases the expression of IFT122ProteinHetionet hetionet:regulates:4189-55764Inferred only
FGFR2 increases the expression of IFT122ProteinHetionet hetionet:regulates:2263-55764Inferred only
KCNG1 increases the expression of IFT122ProteinHetionet hetionet:regulates:3755-55764Inferred only
ZNF684 increases the expression of IFT122ProteinHetionet hetionet:regulates:127396-55764Inferred only

Other names

5 names

Resolves to: IFT122

Also called: SPGWD repeat-containing protein 10WD repeat-containing protein 140WDR10WDR140

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